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Lazio rely on Taty Castellanos, Mattia Zaccagni and Nuno Tavares in their showdown with Serie A leaders Atalanta, who seek a 12th straight victory with Charles De Ketelaere and Ademola Lookman.
It kicks off at the Stadio Olimpico at 19.45 GMT.
The Biancocelesti remain in the hunt for the European places, despite a bruising 6-0 defeat to Inter, recovering to beat Lecce 2-1.
However, it came at a cost, because Tijjani Noslin, Manuel Lazzari, Pedro and Matias Vecino are all out of action.
Loum Tchaouna gets the nod rather than Gustav Isaksen in the trident attack, while Fisayo Dele-Bashiru drops into midfield.
Atalanta are one of the form teams in Europe right now after 11 consecutive Serie A victories to spend Christmas top of the table and are also preparing for the Supercoppa Italiana in Saudi Arabia, where they will face Inter on January 2.
Mateo Retegui, Matteo Ruggeri and Gianluca Scamacca are out of action, with Giorgio Scalvini only fit for a spot on the bench, but Marten de Roon returns from suspension.
De Ketelaere is therefore the False 9 with support from Lookman and Mario Pasalic, while Lazar Samardzic and Nicolò Zaniolo are ready to add some fresh legs.
Lazio vs. Atalanta line-ups
Lazio: Provedel; Marusic, Gila, Romagnoli, Tavares; Guendouzi, Rovella, Dele-Bashiru; Tchaouna, Castellanos, Zaccagni
Atalanta: Carnesecchi; Djimsiti, Hien, Kolasinac; Bellanova, De Roon, Ederson, Zappacosta; Pasalic; De Ketelaere, Lookman
Season Analytics
Lazio
Atalanta
Last matches
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Lazio
Atalanta
