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Inter are forced to reshuffle in defence due to injuries, with Lautaro Martinez and Marcus Thuram upfront against Nico Paz and giant-killers Como.
It kicks off at San Siro at 19.45 GMT.
The Nerazzurri need a victory to keep up with Atalanta and Napoli at the top, albeit with a game in hand.
Along with Benjamin Pavard and Francesco Acerbi, now Matteo Darmian and Stefan de Vrij are also not fully fit, so there has to be some reshuffling in defence.
Nicolò Barella is also carrying a knock, but the front two is Thuram and Lautaro Martinez.
Como are rather an unpredictable team under coach Cesc Fabregas, capable of beating Atalanta 3-2 away from home, but also losing 5-1 to Lazio.
They saw their nine-game winless streak ended by a 2-0 victory over Roma last week to boost confidence.
Maxi Perrone is still out of action, but the injury crisis has largely passed now.
Real Madrid youth product Nico Paz is the danger man behind centre-forward Andrea Belotti, with Sergi Roberto finally fit to start in midfield for the first time since October 25.
Fabregas seemingly moves to a three-man defence.
Inter vs. Como line-ups
Inter: Sommer; Bisseck, Bastoni, Carlos Augusto; Dumfries, Barella, Calhanoglu, Mkhitaryan, Dimarco; Thuram, Lautaro Martinez
Como: Reina; Goldaniga, Dossena, Kempf; Van der Brempt, Sergi Roberto, Da Cunha, Fadera; Nico Paz, Strefezza; Belotti
Inter
Como
