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Inter still have injury issues in defence, but Lautaro Martinez and Marcus Thuram lead the way for the visit to a Cagliari side who raise their game against the big teams.
It kicks off at the Unipol Domus Arena at 17.00 GMT.
The Nerazzurri continue the defence of their title and are three points off leaders Atalanta with a game in hand.
However, this also begins a packed fixture list that includes the Supercoppa Italiana in Saudi Arabia on January 2.
Stefan de Vrij is back in the starting XI after a knee issue, but Matteo Darmian, Francesco Acerbi and Benjamin Pavard are still out of action.
Thuram is now the joint Capocannoniere of Serie A with Mateo Retegui on 12 goals, but Lautaro Martinez has not found the net in Serie A for Inter since November 3.
Cagliari have lost their last three on the bounce, with a 2-1 defeat to Venezia plunging them into the relegation zone.
However, two of those were very narrow 1-0 losses to Atalanta and Fiorentina, while this season they have held Milan, Juventus and Roma to draws, beating Torino and Parma.
Yerry Mina has seemingly shaken off a knock, but Zito Luvumbo is still out with a sprained ankle.
Roberto Piccoli is the centre-forward with Nadir Zortea and Tommaso Augello providing the crosses.
Cagliari vs. Inter line-ups
Cagliari: Sherri; Zappa, Mina, Luperto, Obert; Zortea, Adopo, Makoumbou, Augello; Gaetano; Piccoli
Inter: Sommer; Bisseck, De Vrij, Bastoni; Dumfries, Barella, Calhanoglu, Mkhitaryan, Dimarco; Thuram, Lautaro Martinez
Season Analytics
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Inter
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Cagliari
Inter
