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Taty Castellanos and Alessio Romagnoli return as Lazio try to put the 6-0 defeat to Inter behind them with a trip to unpredictable Lecce.
It kicks off at the Stadio Via del Mare at 19.45 GMT.
The Biancocelesti had been in sparkling form in Serie A, the Europa League and Coppa Italia, including back-to-back victories over Napoli and a 3-1 triumph away to Ajax.
However, they were knocked right back down to earth with a 6-0 hammering on home turf by Inter.
Castellanos was suspended for that game and returns here, but Patric and Matias Vecino are out of action, while Samuel Gigot, Mario Gila and Alessio Romagnoli are not at 100 per cent.
Lecce are a tricky team to deal with, holding Juventus to a 1-1 draw earlier this month and then beating Monza 2-1.
Andy Pelmard is frozen out, with Kialonda Gaspar, Lameck Banda and Joan Gonzalez all out for the long term.
Antonino Gallo, Kevin Bonifazi and Balthazar Pierret are not fully fit either.
Lecce vs. Lazio line-ups
Lecce: Falcone; Guilbert, Baschirotto, Jean, Dorgu; Coulibaly, Berisha, Rafia; Pierotti, Krstovic, Morente
Lazio: Provedel; Lazzari, Gila, Romagnoli, Nuno Tavares; Guendouzi, Rovella; Isaksen, Dia, Zaccagni; Castellanos
Season Analytics
Lecce
Lazio
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Lecce
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